Troponin-I is one of three subunits that form the troponin complex of the thin filaments of striated muscle.  The troponin complex serves as a calcium-sensitive switch that regulates striated muscle contraction.  Troponin-I binds actin and inhibits actomyosin ATPase activity in the abscence of calcium.  Skeletal muscle Troponin-I exists in two isoforms, TnI-fast and TnI-slow, expressed respectively in fast- and slow-twitch muscle fibers.  The two isoforms are characterized by molecular weights ~21 kDa (fast) and ~22 kDa (slow).  The ratios of slow and fast isoforms vary with muscle source and species.  Skeletal muscle Tn-I offered by TriChem Resources is a mixture of slow and fast isoforms.  It is purified by ion-exchange chromatography in conjunction with calcium dependent affinity chromatography on Troponin-C agarose.

HAZARD TESTING & WARNINGS:

Blood samples from tissue donors used in the manufacture of this product tested negative for HBsAg, Anti-HIV-1/HIV-2, & anti-HCV by FDA approved methods.

CAUTION:

NO TEST CAN GUARANTEE A PRODUCT TO BE NON-INFECTIOUS.  THEREFORE, ALL MATERIAL DERIVED FROM HUMAN FLUIDS OR TISSUES SHOULD BE CONSIDERED AS POTENTIALLY INFECTIOUS.

Use Statement: For Research, Remanufacturing, or Immunization use for products not subject to license under PHS Act Section 351 only.